Ayers was an explosive, if undersized, running back from Texas when he arrived on the UH campus, but left after three years as one the best combination slot receiver/return specialists in the country. Getting the ball in his hands was important to Houston coaches, so he lined up as the primary kick returner as a true freshman, earning first-team All-AAC honors (37-1,021, one TD) while working his way into a starting spot the final three games of the year (11-130, one TD receiving). Ayers continued to return kicks in his sophomore year (34-592) but also started eight games as a receiver (33-335, two TD). With the exciting Greg Ward, Jr. operating as the team's quarterback (and leading rusher) in 2015, Ayers fed off that energy to earn first-team all-conference with 98 catches for 1,222 yards and six scores while going back to his roots as a running back at times (25-147, one TD rushing). He also moved from returning kickoffs to taking back punts, earning first team accolades there as well (28-290, one TD). In the Cougars' Peach Bowl win over Florida State, Ayers threw for a touchdown, too. That meant he had done just about everything he could as a collegiate offensive weapon, so he decided to head to the NFL instead of returning with Ward for another run in 2016